Posts Tagged ‘HIV-1’

Ancestor Virus on HIV-1 & HIV-2


Biologists concerned with the origin of species, family trees are the origin of species maps. On a pedigree you can see which species are closely related to each other and their common ancestor. A family can make based on appearance. So paleontologists managed on the basis of fossils to create a family tree showing how to read a prehistoric horse has evolved to a horse as we see trot in the pasture. But a tree does not only the origin of species to map out long since become extinct. You can also create a family tree of your own origins which are your direct ancestors. A tree containing yourself, your father and mother, your grandparents and your grandparents instance you can make under contract by using pictures. But probably a more reliable pedigree under the line of your DNA. Your DNA seems more like your father than that of your grandfather, because you’re more akin to your father or your grandfather. Now for a pedigree of the HIV DNA has been making a lot of different variants of the virus compared. To find out which “ancestor virus” on HIV-1 and HIV-2 belongs to biologists find a virus whose viral DNA resembles that of HIV-1 or HIV-2. They look as it were closely related viruses, like, cousins of HIV.
This nephews and niece viruses found in monkeys in Africa. The nephew of HIV called SIV. The S in SIV simian comes from the English word that means ape-like. There are already 26 known species of monkeys that carry the virus, ranging from chimpanzees. Monkeys infected with SIV themselves are not ill and get no monkey-AIDS, but the virus can transmit it to other monkeys and people. This is described further reading.

Human Immunodeficiency Virus (HIV)

Since 1981, cases were detected striking infection Pneumocystis jiroveci (formerly named Pneumocystis carinii), a fungus related to the original forms of the Ascomycetes, known to infect severely immunocompromised patients. Initially there was a group of similar cases in which gay men were involved and where time appeared to cytomegalovirus infection, and Candidiasis. First thought that the cause should be linked to common practices among male homosexual population.

He soon began to appear cases involving heterosexual male or female intravenous drug users and their children, and also between patients and healthy habits homosexuals who had received transfusions of whole blood or blood products by hemophiliacs condition. Soon it was thought, by epidemiological criteria basically, that the cause must be an infectious agent transmitted in a similar way as does the hepatitis B virus
HIV-1 virions assembled at the surface of a lymphocyte.

Several teams started to get a virus associated with known cases of acquired immunodeficiency, perhaps as a retrovirus known to be produced immunodeficiency cat or HTLV, producer of a type of leukemia. In 1983, at the Pasteur Institute in Paris, a team dedicated to investigating the relationship between retroviruses and cancer led by JC Chermann, F. Barre-Sinoussi, and L. Montagnier found a candidate who called lymphadenopathy-associated virus (lymphadenopathy-associated virus, LAV).

In 1984 the team of R. Gallo, discoverer of HTLV, the only human retrovirus known then, confirmed the discovery, but calling the virus human T lymphotropic virus type III (human T-lymphotropic virus type III, with the acronym HTLV-III). There was a subsequent dispute over the priority in which it became clear that Gallo had described the virus only after receiving samples from the French. As part of resolving the conflict, the virus acquired its final name, human immunodeficiency virus (HIV) in Castilian is expressed as human immunodeficiency virus (HIV).

In the same year, 1983, which identified the virus, several teams began work on its genome sequence published in early 1985, and also began the characterization of proteins.