Daily Health Advices

USE OF ANTI-INFLAMMATORY

Carry out their anti-inflammatory action through numerous and complicated chemical reactions, which enters is the regulation of molecules called prostaglandins, which promote the defenses of the stomach against gastric acid.

The anti-inflammatory inhibit the synthesis of prostaglandins PGs, by which the stomach loses its ability to defend itself, to the point that these drugs, taken continuously, gastric unprotected and uncontrolled, very often lead to gastrointestinal ulcers or minor manifestations of the same etiology.

In the stomach mucosa is well prepared to withstand a pH <2.5.

It counts with several lines of defense:

mucus-bicarbonate layer (see Figure C), which maintains a pH gradient of 2.5 to 7.0 between the surface and deep layer.
the intercellular cohesion phenomena themselves exert mechanical barrier (see Figure D).
microcirculation is also regulated by prostaglandins PGs. (see Figure G).
if the mucosa is adapted to the acidic environment means that for mucosal lesions appear (see Figure E) should be to alter some of these defense mechanisms.
Duodenal ulcer (F): The mechanisms of injury to produce a gastric ulcer are:

Anti-inflammatory drugs (B), both orally and by other means come to the gastric mucosa and are losing the protective outer coating (C).
Infection with the bacterium Helicobacter pylori (A) that flourishes in the gastric mucosa.

Diagnosis

The courtship is fairly typical symptom diagnosis. Is often complemented by performing a gastroscopy, to see the lesions, biopsy of the lesions for analysis and culture for Helicobacter pylori.

Control of Helicobacter pylori infection can be performed by a simple test that measures the CO2 in the breath. This is done by administration through the mouth of Carbon *- marking / Urea and mixed with citric acid, if the patient is Helicobacter pylori Urease produced by this bacteria, are transformed into CO2 and ammonia.

*- Labeled carbon / Urease Urea + = C02 + NH3

The CO2 released through the blood appears in the breath through the lungs. The measurement of CO2 marking is done in two takes, basal and half hour to take the Carbon *- Urea. The sensitivity of the test is 90% and specific in 95% of cases. This analysis can be given to control infection or to continue with longer treatment.

General on the treatment of gastroduodenal ulcer

Antibiotic treatment is indicated in all patients with Helicobacter pylori infection (85% of patients with gastric ulcer at present).

There is no ideal antibiotic therapy, there are several options.

Antiulcer therapy (AntiH2-omeprazole) is recommended to relieve symptoms and promote healing.

The rebels ulcers require a combination of antibiotic secretion inhibitors.

Maintenance treatment is indicated in these ulcers rebels.

In all ulcer patients should be investigated the use of NSAIDs (nonsteroidal anti-inflammatory).

In ulcers associated with NSAIDs (nonsteroidal anti-inflammatory drugs) such must be discontinued, if possible, and eradicate Helicobacter pylori, if present.

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